Dexmedetomidine and ST-91 analgesia in the formalin model is mediated by α2A-adrenoceptors: a mechanism of action distinct from morphine

摘要

Background and purpose:Intrathecal administration of α2-adrenoceptor agonists produces potent analgesia. This study addressed the subtype of spinal α2-adrenoceptor responsible for the analgesic effects of i.t. dexmedetomidine and ST-91 in the formalin behavioural model and their effects on primary afferent substance P (SP) release and spinal Fos activation.