High-throughput RNA sequencing from paired lesional- and non-lesional skin reveals major alterations in the psoriasis circRNAome

摘要

Characterization of circular RNAs in lesional- and non-lesional skin using RNA-seq. Expression levels of the top 50 most abundant circRNAs in non-lesional skin and lesional skin Each dot represents the expression in reads per million (RPM) for a circRNA in one individual sample represented by a unique color. Each line represents the mean RPM. Black arrows indicate top 10 alpha circRNAs and red arrows indicate circRNAs not present in circBase. Histograms showing the number of host genes producing various numbers of unique high abundance circRNAs in non-lesional skin and in lesional skin . Pie charts showing the distribution of the numbers of exons annotated within the high abundance circRNAs in non-lesional skin and lesional skin