初发系统性红斑狼疮患者外周血清IL-17的表达

摘要

Objective To investigate the levels and clinical significance of serum interleukin 17(IL- 17) in patients with on-set systemic lupus erythematosus. Methods Serum IL- 17 in 46 SLE patients and 26 healthy controls were analyzed by enzyme linked immunosorbent assay (ELISA).Levels of anti- dsDNA , immunoglobulin and complement were also measured. Results The serum IL- 17 level were higher in both active or inactive SLE patients than to healthy controls (P<0.05).There was no differ-ence in serum IL- 17 level in active or inactive SLE patients(P>0.05).Higher serum IL- 17 level was found in patients with cuta-neous manifestations compared to those without (P<0.05).Patients who received cyclophosphamide were found to have higher serum IL- 17 levels than those who not taking this medication (P<0.05).IL- 17 had no correlation with SLEDAI, ESR, CRP, IgG, complement C3 and C4 (P>0.05), while had significant negatively correlation with SLEDAI (P<0.05).The serum IL- 17 levels of 19 active SLE patients decreased significantly after one months (P<0.05). Conclusion IL- 17 was found to be related to cuta-neous manifestations in SLE patients.IL- 17 may play an important role in the pathogenesis of SLE and was linked with the seri-ousness of SLE.%　　目的探讨IL-17在初发系统性红斑狼疮（SLE）患者外周血清中的表达水平及其临床意义。方法选择42例初次诊断、未经治疗的SLE患者（SLE组）及26例同期健康志愿者（对照组），采用双抗体夹心酶联免疫吸附试验（ELISA）方法测定外周血清IL-17水平，同时检测外周血抗ds- DNA等抗体及免疫球蛋白、补体等水平并进行相关分析。结果活动期和缓解期SLE患者血清IL-17水平均较对照组明显升高，差异均有统计学意义（均P＜0.05）。活动期和缓解期SLE患者间血清IL-17水平的差异无统计学意义（P＞0.05）。具有皮肤损害的SLE患者血清IL-17水平较无皮肤损害者高，使用环磷酰胺的SLE患者血清IL-17水平较未使用环磷酰胺者高，差异有统计学意义（P＜0.05）。SLE患者血清IL-17水平与SLEDAI、血沉、CRP、IgG、C3、C4均无相关性（均P＞0.05）。19例SLE活动期患者治疗1个月后血清IL-17水平较治疗前明显下降，差异有统计学意义（P＜0.05）。结论 IL-17与狼疮患者的皮肤损害密切相关；IL-17在SLE的发病中起到重要作用并与疾病严重性有关。