头颈部腺样囊性癌及癌旁组织中mir-21的表达

摘要

目的：通过检测头颈部腺样囊性癌（HNACC）及癌旁组织中mir-21的相对表达量，分析其与HNACC临床病理特征的关系。方法采用实时荧光定量PCR技术检测36例HNACC组织和19例癌旁组织中mir-21的表达量。结果 mir-21在ACC组织中的表达量明显高于癌旁组织，差异有统计学意义（P＜0.01）；转移复发组的mir-21表达量高于非转移复发组，差异有统计学意义（P＜0.05）；不同年龄、性别、神经累及、骨累及以及不同TNM分期的mir-21的表达量的差异均无统计学意义（均P＞0.05）。结论 mir-21的高表达与HNACC的发生、发展可能存在密切联系，且在其复发和转移中可能发挥着一定的作用。%Objective To investigate the expression of mir- 21 in adenoid cystic carcinoma of head and neck (HNACC) and its clinical significance. Methods The expression of miR- 21 was detected by real- time fluorescence quantitative PCR in 36 samples of HNACC tissue and 19 samples of para- carcinoma tissue. Results The expression of mir- 21 was significantly higher in HNACC tissues compared to para- carcinoma tissues (P<0.01). The expression of mir- 21 of metastasis and/or recurrence group significantly higher than non- metastasis and recurrence group (P<0.05). Conclusion Results indicate that high expres-sion of mir- 21 may be related to the development of HNACC, and it may also be involved in the metastasis and recurrence of HNACC.