康艾注射液联合NP方案治疗晚期NSCLC患者的临床效果观察

摘要

Objective To observe the clinical effect of Kangai injection combined with NP regimen in the treatment of advanced non-small cell lung cancer. Method Collect 76 patients with non-small cell lung cancer inⅢ~Ⅳstage,they were divided into the control group and observation group randomly,compared with that the clinical effect after 2 course of treatment,Karnofsky score and adverse reactions in the course of treatment. Result There was no significant(P>0.05)in the number of complete remission and disease progression cases,there was a significant(P<0.05)in the number of partial response and stable disease cases, the observation group was better than the control group;there was a significant(P<0.05)in the Karnofsky score in the course of treatment,the observation group was better than the control group;there was no significant(P>0.05)in the adverse reactions in the course of treatment. Conclusion During treating the advanced NSCLC patients by NP regimen,Kangai injection therapy should be added,it could improve the clinical effect and did not increas the adverse reactions.%　　目的观察康艾注射液联合NP方案治疗Ⅲ~Ⅳ期非小细胞肺癌的临床效果。方法选择同期Ⅲ~Ⅳ期非小细胞肺癌患者76例，随机均分为对照组和观察组，每组各38例。对照组给予NP方案治疗，观察组给予康艾注射液联合NP方案治疗，连续治疗2个疗程后比较两组患者临床疗效、生活质量评分（Karnofsky评分）及治疗过程中的不良反应。结果治疗2个疗程后，两组患者完全缓解与疾病进展病例数比较，差异无统计学意义（P>0.05），部分缓解与疾病稳定病例数比较，差异有统计学意义（P<0.05），观察组优于对照组；治疗1个疗程和2个疗程后，Karnofsky评分比较，差异有统计学意义（P<0.05），观察组优于对照组；治疗过程中出现的不良反应例数比较，差异无统计学意义（P>0.05）。结论采用NP化疗方案治疗晚期NSCLC患者时，应加用康艾注射液治疗，可提高患者临床疗效与生活质量，且不增加化疗过程中的不良反应。