聚甘油接枝改性琥珀酸单胆固醇酯的研究

摘要

The cholesteryl hemisuccinate was grafting modified with polyglycerol using p-TSA as catalyst, dimethylbenzene as solvent. The effects of catalyst dosage, reaction time and mole ratio of raw material on the product were investigated. It was found as follow:reaction time 3 h, mole ratio of polyglycerol to cholesteryl hemisuccinate 1.2 and p-TSA dosage 15% of the mass of cholesteryl hemisuccinate.Under the condition,the yield of product was up to 66%.The chemical structure and physical properties were tested by FT-IR and melting point.%以二甲苯为溶剂，对甲苯磺酸为催化剂，用聚甘油对脂质体琥珀酸单胆固醇酯酯化反应的方法接枝改性。通过正交试验考察了催化剂、反应时间及投料比等对收率的影响，结果表明：n（胆固醇单琥珀酸酯）：n（二聚甘油）=1：1.2，反应时间为3 h，催化剂的用量为胆固醇单琥珀酸酯质量的15%，聚甘油胆固醇琥珀酸酯的收率可达66%。并用红外光谱对产品的化学结构进行表征。