Reticular erythematous mucinosis(REM)is a rare,primary cutaneous mucinosis clinically characterized by a persistent reticular erythema on the mid chest and mid-upper back,and histologically by a mononuclear cell infiltrate and deposits of mucin in the dermis.To our knowledge,the present report of REM occurring in a Caucasian man and his sister is the first reported case of familial REM.Since a host-specific immune response to unknown antigens may be involved in the pathogenesis of this entity,human leukocyte antigen typing was determined and compared to those reported in autoimmune diseases.
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