Establishing a structured animal model for screening anti-psychological drugs of schizophrenia

摘要

Although some traditional animal models for studying schizophrenia have been wildly used,many problems remain in their credibility and validity.We propose that structured animal models with the integration of multiple symptom-inducing factors are be better in simulating the symptoms of schizophrenia and represent the new direction of the future ani-mal-model development.In this article,we review previous studies in this line of research and emphasize the importance of combining the behavior paradigm of the structured top-down attentional modulation of prepulse inhibition with multiple path-ogenic factors related to schizophrenia to establish a new model generation,which will be of great significance in investigating both the pathogenesis and the treatment of schizophrenia.