目的:探讨黏附分子L1在胃肠道间质瘤(GIST)中的表达情况及其临床意义.方法:采用免疫组织化学法和RT-PCR检测66例GIST、10例平滑肌肿瘤、6例神经鞘瘤及14例正常肠壁组织中L1的表达情况,并分析其临床意义.结果:胃肠道间质瘤中L1蛋白及mRNA的表达率分别为57.6％(38/66)和83.3％ (30/36),差异有统计学意义(P＜0.05)；L1在不同侵袭危险性GIST中的表达差异有统计学意义(P＜0.05),但在不同性别、年龄、肿瘤部位、组织学类型中的表达差异无统计学意义(P＞0.05).L1在GIST中的表达明显高于其在平滑肌肿瘤及正常肠组织中的表达(P＜0.01),与其在神经鞘瘤中的表达差异无统计学意义(P＞0.05).结论:L1表达在GIST发生发展过程中起促进作用,L1可作为GIST的诊断和鉴别诊断指标.%Objective: To investigate the expression of the adhesion molecule L1 in gastrointestinal stromal tumors (GIST),and the clinical significance thereof. Methods: The expression levels of LI were detected in tissues of 66 samples of GIST,10 samples of smooth muscle tumors,6 samples of schwannoma and 14 samples of normal bowel by immunohistochem-istry and RT-PCR,and their clinical significances were analyzed. Results! The expression rates of LI protein and mRNA in GIST were 57.6% (38/66) and 83.3% (30/36),which were significantly different between two groups (P < 0.05). The L1 expression was significantly different in the different aggressive risk of GIST (P < 0.05),but there was no significant difference in different age,gender,tumor locus and tissue type groups (P > 0.05). The expression of L1 was significantly higher in GIST than that of smooth muscle tumor and normal bowel tissues (P < 0.01). There was no significant difference in the expression of L1 between GIST group and schwannoma groupss (P > 0.05). Conclusion: The expression of L1 may play an important role in tumorigenesis and progression of GIST,which suggest that L1 can be applied to diagnosis or differential diagnosis of GIST.
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