Objective To observe the curative effect of plasma perfusion (PP) combined with continuous veno-venous hemofiltration (CVVH) on different degrees of paraquat poisoning induced acute lung injury (ALI), and assess its clinical value for treatment of paraquat poisoning. Methods Data of 197 patients with paraquat poisoning hospitalized in our hospital from June 2013 to April 2017 were retrospectively analysed, including 128 cases with mild-to-moderate poisoning (5 mg·h/L≤SIPP≤25 mg·h/L) and 69 cases with severe poisoning (25 mg·h/L0.05). (2) There was no significant difference in the occurrence time of irreversible lung injury between two groups of patients with different degrees of poisoning (P>0.05). (3) The blood toxicant concentration of 4.35 mg·h/L and SIPP value 19.35 mg·h/L were used as a critical indicator of prognosis in treatment group. Conclusion Plasma perfusion combined with continuous veno-venous hemofiltration can obviously reduce the incidence of paraquat poisoning of lung injury in mild-to-moderate patients, but which has no obvious influence on the occurrence time.%目的 通过观察对比血浆吸附灌流(PP)联合连续性静-静脉血液滤过(CVVH)对不同程度百草枯中毒导致急性肺损伤(ALI)的治疗效果,评估该方法 治疗百草枯中毒的临床价值.方法回顾性分析2013年6月—2017年4月于我院住院治疗的百草枯中毒患者197例,其中轻中度中毒[5 mg·h/L≤中毒严重指数(SIPP)≤25 mg·h/L]128例,重度中毒(25 mg·h/L0.05).(2)不同中毒程度2组患者不可逆肺损伤出现时间差异均无统计学意义(P>0.05).(3)可把血毒物浓度4.35 mg·h/L、SIPP值19.35 mg·h/L作为治疗组判断预后的临界指标.结论 采用PP联合CVVH治疗能够明显减少轻中度百草枯中毒肺损害的发生率,但对其发生时间无明显影响.
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