慢性阻塞性肺疾病和心脏性猝死相关性的研究进展

摘要

慢性阻塞性肺疾病(COPD)和心脏性猝死(SCD)都给人类健康带来了沉重的负担.许多证据表明COPD与发生SCD风险的增加有关.首先,在研究COPD与恶性室性心律失常及心脏停搏的相关性时,研究人员发现,与COPD相关的死亡患者中,表现为心脏停搏和无脉性电活动(PEA)相比室速、室颤更加普遍,其机制仍有待进一步研究.其次,在研究COPD和SCD心电图标志的相关性时,研究人员发现COPD与QT(QTc)间期延长和缩短均相关.第三,在研究应用改善呼吸症状的药物对发生SCD的潜在影响时,研究人员得出了矛盾的结论.目前在广泛人群中精准预测SCD仍是一大挑战,通过研究COPD和SCD的相关性,可能会对SCD的风险评估有指导作用.%Both chronic obstructive pulmonary disease (COPD) and sudden cardiac death (SCD) are major health burdens.In conclusion,cumulating evidence associates COPD with an increased risk of SCD.First,it is found that asystole and pulseless electric activity(PEA)are more common than ventricular tachycardia/ventricular fibrillation(VT/VF)in deaths associated with COPD in studying interrelationship between COPD and ventricul ararrhythmias and cardiac arrest. The underlying mechanism explaining this association requires further investigation.Second,it is found that COPD is associated with a prolonged and shortened QT interval in studying the role of ECG markers between SCD and COPD.Finally,studies of the potential impact of respiratory treatment on the occurrence of SCD showed conflicting results.Accurate prediction of SCD in the general population is still a challenge. The risk assessment of SCD might be guided by studying the link between COPD and SCD.