目的：探讨鲑降钙素联合仙灵骨葆治疗绝经后妇女骨质疏松症所致骨痛疗效情况。方法分析该院骨科2014年8月一2016年2月收治的55例绝经后妇女骨质疏松症所致骨痛患者临床资料,依据治疗措施进行分组,对照组25例患者单纯给予阿仑磷酸钠治疗,联合治疗组30例患者给予鲑降钙素联合仙灵骨葆治疗。观察两组绝经后妇女骨质疏松症所致骨痛患者血钙、血磷、BMD、碱性磷酸酶(AKP)、骨钙素(BGP)、临床总有效率、不良反应发生情况。结果两组绝经后妇女骨质疏松症所致骨痛患者治疗前血钙(2.35±0.31)mmol/L和(2.36±0.33) mmol/L、血磷(1.69±0.21)mmol/L和(1.68±0.22)mmol/L、BMD(0.80±0.10)g/cm和(0.81±0.11)g/cm、AKP(157.5±15.2) IU/L和(158.4±15.8)IU/L、BGP(4.4±2.1)μg/L和(4.5±2.0)μg/L均差异无统计学意义,P>0.05,两组绝经后妇女骨质疏松症所致骨痛患者治疗后血钙(2.36±0.32)mmol/L和(2.37±0.30)mmol/L、血磷(1.69±0.30)mmol/L和(1.61±0.20) mmol/L、BMD(0.84±0.11)g/cm和(0.89±0.12)g/cm、BGP(5.3±1.9)μg/L和(5.8±2.1)μg/L差异均无统计学意义,P>0.05,联合治疗组和对照组治疗后AKP(99.9±8.4)IU/L和(90.2±6.5)IU/L低于治疗前,联合治疗组治疗后AKP低于对照组,联合治疗组绝经后妇女骨质疏松症所致骨痛患者临床总有效率93.3%高于对照组72%,联合治疗组绝经后妇女骨质疏松症所致骨痛患者不良反应发生率0低于对照组20%,差异均有统计学意义P<0.05。结论鲑降钙素联合治疗绝经后妇女骨质疏松症所致骨痛临床症状改善明显,效果良好,值得临床推广应用。%Objective To approach curative effect of post-menopause osteoporosis caused by stalgia by salmon calci-tonin with fairy bone remains. Methods The 55 cases clinical data of post-menopause osteoporosis caused by stalgia patients in our hospital orthopedics from August 2014 to Febuary 2016were analyzed,which was to be divided into two groups by different treatment methods,control group 25 cases gived alendronate treatment,combined treatment group 30 cases gived stalgia by salmon calcitonin with fairy bone remains treatment. The blood calcium、serium inorganic phos-phorus、BMD、AKP、BGP、clinical total effective rate、adverse reactions rate of two groups post-menopause osteoporosis caused by stalgia patients were detected. Results The blood calcium(2.35±0.31)mmol/L and (2.36±0.33)mmol/L、seri-um inorganic phosphorus(1.69±0.21)mmol/L and(1.68±0.22)mmol/L、BMD(0.80±0.10)g/cm and(0.81±0.11)g/cm、AKP (157.5±15.2)IU/L and(158.4±15.8)IU/L、BGP(4.4±2.1)μg/L and(4.5±2.0)μg/L of two groups post-menopause osteo-porosis caused by stalgia patients before treatment were no difference,P>0.05,The blood calcium (2.36 ±0.32)mmol/L and (2.37±0.30)mmol/L、serium inorganic phosphorus(1.69±0.30)mmol/L and(1.61±0.20)mmol/L、BMD(0.84±0.11)g/cm and(0.89±0.12)g/cm、BGP(5.3±1.9)μg/L and(5.8±2.1)μg/L of two groups post-menopause osteoporosis caused by stalgia patients after treatment were no difference,P>0.05,The AKP (99.9±8.4)IU/L and (90.2±6.5)IU/L of combined treatment group and control group after treatment were lower than before treatment,the AKP of combined treatment group were lower than control group,the clinical total effective rate 93.3% of combined treatment group post-menopause osteoporosis caused by stalgia were higher than control group72%,the adverse reactions rate 0 of combined treatment group post-menopause osteoporosis caused by stalgia were lower than control group20%,P<0.05,the differ-ence were statistical significance. Conclusion The clinical symptoms of post-menopause osteoporosis caused by stalgia by salmon calcitonin with fairy bone remains could obviously improve,the result is good,which is to be used.
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