香豆素类化合物在肿瘤治疗上的应用

摘要

Coumarins are a group of compounds with anα-benzopyrone structure.In recent years,the researchers have explored the influence of coumarins on enzymes and cell pathways related to the metabolism of tumor cells,and isolated or synthesized many structurally specific coumarin derivatives with excellent anti-tumor activity,which proves adequately the importance of coumarin skeleton in the research and development of anticancer drugs.In this paper, we reviewed the application of many natural and synthetic coumarins which are classified by classical coumarin struc-tures on exploring new anticancer drugs.%香豆素（ Coumarins）的基本结构是苯骈α－吡喃酮的一类化合物。近年来研究者报道了在肿瘤细胞信号转导通路和代谢的影响上香豆素具有的作用，从而发现了香豆素类化合物具有的抗肿瘤活性，并充分证明了目前香豆素类化合物在抗癌药物研发中的重要性。本文以香豆素的基本结构进行分类，对香豆素类化合物的抗肿瘤作用的研究进展进行综述。