KLF-6在口腔扁平苔藓恶变中的表达研究

摘要

目的 探讨KLF-6在口腔扁平苔藓发病机制及癌变中的作用.方法 分别采用免疫组化和Western-blot方法对10例正常口腔黏膜、30例扁平苔藓患者和22例口腔鳞癌患者的上皮组织中KLF-6蛋白进行t检测,比较其在三者之间的差异.SPSS 14.0对数据进行检验.结果 扁平苔藓患者组织中KLF-6蛋白的表达明显低于正常口腔黏膜,两组之间具有显著性差异;口腔鳞癌患者组织中KLF-6蛋白的表达明显低于扁平苔藓组织,两组之间具有显著性差异.结论 KLF-6的表达异常可能在口腔扁平苔藓的发生发展及癌变的过程中起作用.%Objective To examine the function of KLF-6 in the oral lichen planus pathogenesis and canceration. Methods Immu-nohistochemistry and Western-blot were used to examine KLF-6 protein in 10 cases of normal oral mucosa, 30 cases with oral lichen planus and 22 cases with squamous cell carcinoma. SPSS 14.0 software package was used for t test. Results The expression level of KLF-6 protein in 30 cases with oral lichen planus was lower than that in 10 cases with normal oral mucosa and there was significant difference between the two groups(P<0.05).The expression level of KLF-6 protein in 22 cases with squamous cell carcinoma was lower than that in 30 cases with oral lichen planus.(P<0.05)and the two groups had significant difference. Conclusions The abnormal ex-pression of KLF-6 may play a role in the development and carcinogenesis of OLP.