MMP-9和 Fascin 蛋白在口腔扁平苔藓中的表达及相关性研究

摘要

Objective To examine the expression and correlation of MMP-9 and Fascin in oral lichen planus(OLP). Methods The expression of MMP-9 and Fascin in 35 cases of normal oral mucosa,45 cases of oral lichen planus and 46 cases of oral squamous cell carcinoma(OSCC)was examined by immunohistochemical technique.The data was analyzed by SPSS,a exact test using software package.Results the expression of MMP-9 in normal oral mucosa,oral lichen pla-nus and oral squamous cell carcinoma rises in turn.The positive rate respectively is 11.4%(4/35)、66.7%(30/45)、89. 1%(41/46),the comparison among groups is statistically significant(P <0.05);The expression of Fascin in normal o-ral mucosa,oral lichen planus and oral squamous cell carcinoma rises in turn.The positive rate respectively is 0%(0/35)、15.6%(7/45)、69.6%(32/46),the comparison among groups is statistically significant(P <0.05);In oral lichen planus,the expression of MMP-9 is positively correlative with that of Fascin(P <0.05).Conclusion MMP-9 and Fas-cin not only respectively paly an important role in cancerous progress of oral lichen planus but also the two factor work together to promote the cancerous progress.%目的：检测 MMP-9和 Fascin 蛋白在口腔扁平苔藓中的表达情况，探讨两者在扁平苔藓发病机制中的作用及相关性。方法采用免疫组化技术检测 MMP-9和 Fascin 蛋白在35例口腔正常黏膜组织、45例口腔扁平苔藓和46例口腔鳞状细胞癌组织中的表达。应用 SPPSS 软件对实验结果进行卡方检验和 Spearman 相关分析。结果MMP-9在口腔正常黏膜组织、口腔扁平苔藓和口腔鳞状细胞癌组织中的表达依次增高，表达率分别为11．4％（4／35）、66．7％（30／45）、89．1％（41／46），组间差别有统计学意义（P ＜0．05）；Fascin 在口腔正常黏膜组织、口腔扁平苔藓和口腔鳞状细胞癌组织中的表达率依次增高表达率分别为0％（0／35）、15．6％（7／45）、69．6％（32／46），组间差别具有统计学意义（P ＜0．05）；且 MMP-9和 Fascin 蛋白在扁平苔藓中的表达呈正相关（r＝0．427，P ＜0．05）。结论MMP-9和 Fascin 蛋白在口腔扁平苔藓癌变的进展过程中起着重要作用，两者之间起相互协同促进的作用。