苦黄注射液与茵栀黄比较治疗病毒性肝炎的系统评价

摘要

目的 系统评价苦黄与茵栀黄治疗病毒性肝炎的疗效以及安全性.方法 电子检索Cochrane图书馆(2011年第1期)、EMBase( 1974 ～2011)、PubMed( 1978 ～ 2011)、VIP( 1989 ～ 2011)、CBM( 1978 ～2011)、CNKI( 1978 ～ 2011)；手工检索相关杂志.纳入符合标准的随机对照试验(RCT),评价研究质量,提取有效数据,并用RevMan5.0软件进行Meta分析.结果 最终纳入10个随机对照试验,Meta分析结果显示:苦黄在治疗病毒性肝炎时的总有效率比茵栀黄更高,且差异具有统计学意义[ RR=1.30,95％ CI( 1.22,1.38),P＜0.00001]；苦黄与茵栀黄在治疗病毒性肝炎时有相似的不良反应发生率,且差异无统计学意义[OR=1.27,95％ CI (0.33,4.89),P=0.73].结论 本系统评价结果显示,苦黄治疗病毒性肝炎的疗效优于茵栀黄,但因为纳入研究质量较低,尚需高质量,大样本,长期的随机对照试验加以验证.%Objective To evaluate the efficacy and safety of Kuhuang vs Yinzhihuang in the treatment of viral hepatitis. Methods We electronically searched The Cochrane Library (2011, issue 1), EMBase(1974 -2011) , PubMed(1978 -2011) , VIP( 1989 - 2011) , CBM (1978 - 2011) , CNKI (1978 - 2011); relevant magazines were also handsearched. Randomized controlled trails (RCTs) of Kuhuang Vs Yinzhihuang in the treatment of viral hepatitis which included were evaluated and analyzed by the software RevMan 5. 0 . Results 10 studies were finally included. The result of Meta analysis demonstrated that Kuhuang was superior to Yinzhihuang in total effective rate in the treatment of viral hepatitis [ RR = 1. 30, 95% CI ( 1. 22, 1. 38) , P < 0. 00001 ]. There was no statistically difference in incidence of overall adverse events (Aes) [ OR = 1. 27, 95% CI(0. 33, 4. 89) , P =0. 73]. Conclusion Kuhuang is effective and safe for viral hepatitis. The results suggest that further and larger-scale trials u-sing Kuhuang for viral hepatitis.