目的 观察布托啡诺静脉预处理减轻异丙酚注射痛的临床效果.方法 200例拟在静吸复合全身麻醉下行择期妇科手术的患者,随机分为Ⅰ组(0.5mg布托啡诺组)、Ⅱ组(1mg布托啡诺组)、Ⅲ组(利多卡因组)和Ⅳ组(生理盐水对照组),每组50例.所有患者在给药前均先以橡胶止血带阻断其局部静脉回流.Ⅰ组和Ⅱ组分别经静脉给予布托啡诺0.5mg和1mg；Ⅲ组给予利多卡因20mg；Ⅳ组给予生理盐水2ml.1min后松开止血带,并推注1/4预计量异丙酚,同时记录注射部位疼痛评分.结果 4组患者术中异丙酚注射痛发生率分别为:0.5mg布托啡诺组68％,1mg布托啡诺组46％,利多卡因组52％,生理盐水对照组88％.布托啡诺组和利多卡因组注射痛发生率均明显低于对照组(P＜0.05),其中1 mg布托啡诺组注射痛发生率低于0.5mg布托啡诺组(P＜0.05).结论 布托啡诺静脉预处理可以有效减轻异丙酚注射痛.%Objective To observe the clinical effect of vein pretreatment with butorphanol for alleviation of pain on propofol injection. Methods 200 patients scheduled for gynaecological operations under general anaesthesia were randomly divided into four groups; group Ⅰ (0. 5 mg butorphanol group) , group Ⅱ ( 1 nig butorphanol group) , group Ⅲ (lidocaine group) and group IV (control group). 50 patients included in each groups. Patients in group I and group TJ received butorphanol 0. 5mg or lmg respectively , group Ⅲ received lidocaine 20mg, and group Ⅳ received nomal saline 2ml, with venous occlusion for one minute, followed by injection of one-forth of the total propofol into a dorsal hand vein. And pain during injection of propofol was evaluated. Results The incidence rate of pain on propofol injection was 68% in 0. 5mg butorphanol group, 46% in lmg butorphanol group, 52% in lidocaine group, and 88% in control group. We found that there was a significant reduction in the incidence of pain in the butorphanol groups and lidocaine group compared with the control group (P＜0. 05). Butorphanol lmg was more effective than butorphanol 0. 5mg ( P ＜ 0. 05 ). Conclusion Pretreatment with butorphanol is effective in attenuating pain during i. v. injection of propofol.
展开▼
