Objective To compare the effects and adverse reactions of different sedative and analgesic schemes in pa-tients after cardiopulmonary bypass. Methods After adult cardiopulmonary bypass surgery,the patients were randomly divided into two groups. Patients recovered completelywere respectively used propofol fentanyl or midazolam fentanyl short-term(24h) of seda-tion and analgesia. The patient’s circulation index and adverse reactions were observed. Results There was no significant differ-ence between the two groups at the same observation point(P>0. 05). Within the group of the same patient before and after the comparison,the cycle index was volatile, but the difference was not statistically significant ( P >0. 05 ) . The extubation time of propofol group(151. 1 ± 44. 9min)was significantly less than the midazolam group(208. 1 ± 46. 5min). Adverse events in the two groups,the incidence of vomiting were both higher,and the incidence of pain was higher in the propofol group(3/32 vs. 0/31). Conclusions For patients after cardiopulmonary bypass surgery,the two schemes can provide good sedative and analgesic effects, and have little effect on the circulatory function. Compatibility in the propofol group can shorten extubation time,but after the end of administration,the later analgesic therapy of patients should be strengthened,and using midazolam group compatibility is helpful for analgesia. Two programs in the use of the process should both pay attention to the prevention of vomiting.%目的：比较心脏体外循环术后患者使用不同镇静镇痛方案时的效果及不良反应。方法成人心脏体外循环术后患者随机分为两组，待意识完全恢复后分别使用丙泊酚+芬太尼或咪唑安定+芬太尼进行短时(<24h)镇静镇痛，观察其循环指标及不良反应。结果同一观察时点的循环指标两组间比较差异无统计学意义( P>0．05)；组内同一患者自身前后对比，循环指标有波动，但差异亦无统计学意义(P>0．05)。拔管时间丙泊酚组(151．1±44．9min)明显少于咪唑安定组(208．1+46．5min)。两组不良事件中，呕吐的发生率均较高，而疼痛发生率丙泊酚组更高(3/32 vs.0/31)。结论心脏体外循环术后患者，采用该两种方案均可提供良好的镇静镇痛，且对循环功能影响小。丙泊酚组配伍，可缩短拔管时间，但停药后需加强后续的镇痛治疗，使用咪唑安定组配伍则利于镇痛。两种方案在使用过程中均应注意预防呕吐。
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