血细胞分离术在骨髓增殖性肿瘤中应用临床疗效观察

摘要

Objective To investigate the clinical efficacy of therapeutic blood cell separation in the treatment of hemato-logical diseases. Methods For patients with myeloproliferative disorders and abnormally elevated blood cells,we made treatment plan of apheresis of red blood cells,white blood cells,and platelet,by application of COM TEC( Germany) blood cell separator. Blood cells were separated by continuous blood cell separation. The therapeutic effects and adverse reactions were observed. Re-sults The average total circulating amount of red blood cells was 2303. 06mL,and the average number of red blood cells was 1248. 87mL. The average amount of single cell cycle was 4882. 88mL,and the average white blood cell count was 418. 61mL. The average total circulation of platelet apheresis was 6393. 6mL,and the average platelet count was 493. 40mL. Comparisonof blood routine before and after Therapeutic blood cell single collection,after apheresis of red cells,RBC decreased from(7. 11 ± 0. 95) × 1012/L to(5. 78 ± 1. 03) × 1012/L,HGBdecreased from(193. 24 ± 15. 15) g/L to(158. 72 ± 19. 92) g/L. After apheresis of white cells,WBC decreased from(335. 71 ±184. 69) ×109/L to(288. 09 ±153. 68) ×109/L;HGB decreased from(71. 66 ±14. 92)g/Lto(65.83±15.58)g/L.After apheresis of platelet,PLT decreased from(1275.80±423.33)×109/Lto(899.10±491.73)× 109/L. All differences were statistically significant(P<0. 05). Conclusion Therapeutic blood cells apheresis can effectively and selectively reduce the number of blood cells in patients,alleviate a series of clinical symptoms due to abnormal increase of blood cell count,reduce the incidence of complications such as embolism, bleeding, improve the clinical efficacy of the drug, and win treatment time for patients to further treatment of the disease itself.%目的 探讨治疗性血细胞分离术在血液病中的应用临床疗效观察.方法 对于血细胞异常增高骨髓增殖性疾病患者,制定治疗方案进行红细胞、白细胞、血小板单采术,应用COM TEC(德国)血细胞分离机,采用连续性血细胞分离法进行血细胞分离.观察治疗效果及不良反应.结果 红细胞单采一次平均循环总量为2303.06mL,采集红细胞量平均为1248.87mL;白细胞单采一次循环总量平均为4882.88mL,采集白细胞量平均为418.61mL;血小板单采一次平均循环总量为6393.6mL,采集血小板量平均为493.40mL.治疗性血细胞单采术前后血常规比较,红细胞单采术后RBC由(7.11±0.95)×1012/L降至(5.78±1.03)×1012/L,HGB由(193.24±15.15)g/L降至(158.72±19.92)g/L;白细胞单采术后WBC由(335.71±184.69)×109/L降至(288.09±153.68)×109/L;HGB由(71.66±14.92)g/L降至(65.83±15.58)g/L;血小板单采术后PLT由(1275.80±423.33)×109/L降至(899.10±491.73)×109/L,差异均有统计学意义(P<0.05).结论 治疗性血细胞单采术可以高效选择性降低患者体内血细胞的数量,缓解因血细胞计数异常增高出现的一系列临床症状,降低栓塞、出血等并发症的发生,提高临床药物疗效,为患者进一步治疗本身疾病赢得治疗时间.