Objective To explore the effect of recombinant human brain natriuretic peptide on the treatment of heart failure after acute myocardial infarction and its effect on endothelial function and inflammatory factors.Methods Seventy-nine cases of patients with heart failure after acute myocardial infarction in our hospital from April 2014 to July 2016 were randomly devided into observation group and control group,39 cases in the control group,and 40 cases in the observation group.The control group was treated with intravenous injection of nitroglycerin,and the observation group received intravenous injection of recombinant human brain natriuretic peptide.The levels of endothelin-1 (ET-1),NO,hs-CRP and IL-6 in the two groups were observed and compared before and after treatment,the clinical efficacy and the incidence of adverse reactions between the two groups were compared as well.Results The total effective rate was 90％ in the observation group,which was higher than that in the control group (72％,P ＜0.05);the levels of ET-1,IL-6 and hs-CRP in the observation group were lower than those in the control group (P ＜0.05);the difference of the incidence of adverse reactions after treatment between the groups was not statistically significant (P ＞0.05).Conclusion The effect of recombinant human brain natriuretic peptide on the treatment of heart failure after acute myocardial infarction is significant,it can improve endothelial function,inflammatory factor levels,and reduce the incidence of adverse reactions.%目的 探讨重组人脑利钠肽治疗急性心肌梗死后心力衰竭临床疗效及对内皮功能、炎症因子的影响.方法 选取我院2014年4月至2016年7月收治的79例急性心肌梗死后心力衰竭患者,按随机数字表法分组,对照组39例,观察组40例,对照组静脉注射硝酸甘油治疗,观察组静脉注射重组人脑利钠肽治疗,观察比较2组治疗前后内皮素-1(ET-1)、NO水平及超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)水平,并统计对比2组临床疗效及不良反应发生情况.结果 观察组治疗总有效率为90％,高于对照组72％,差异具有统计学意义(P＜0.05);治疗后观察组NO水平高于对照组,ET-1及IL-6、hs-CRP水平均低于对照组,差异具有统计学意义(P＜0.05);治疗后不良反应发生率组间比较,差异无统计学意义(P＞0.05).结论 重组人脑利钠肽治疗急性心肌梗死后心力衰竭,疗效显著,且可改善患者内皮功能、炎症因子水平,减少不良反应的发生.
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