5H -呋喃酮的合成

摘要

The compounds with structure of 5H -furanones exist in a large number of natural products , and show a wide range of biological activities .5 H -furanone is organic synthesis of five ring lactone compounds key intermediates , some spices can be used for material and natural product synthesis , drug and biological substances is important in the Status . This text used in the synthesis of a new line to furfural and N ,N -Dimethyla cetamide and Formic acid and Hydrogen peroxide as the main raw material, the oxide of cis -obtained target product.%含5H -呋喃酮结构的化合物广泛存在于天然物质当中，具有多种生物活性。5H -呋喃酮是有机合成中合成五元内酯化合物的重要中间体，可用于一些香料物质和天然产物的合成，在药物和生物活性物质中具有重要的地位。本文中采用了全新的合成路线，以糠醛、二甲基乙醇胺、甲酸、双氧水为主要的原料，经氧化合成得到目标产物。