叶酸对女性冠心病患者血清同型半胱氨酸水平的影响

摘要

目的:探讨叶酸对女性冠心病伴高同型半胱氨酸(Hcy)血症患者的血清Hcy水平的影响.方法:对女性冠心病患者49例和正常对照组女性50例,采用荧光标记免疫检测法测定空腹血清Hcy水平,Hcy≥15μmol/L为高Hcy血症,将42例高Hcy血症女性冠心病患者随机分为对照组(20例,仅服用硝酸酯类、他汀类及肠溶阿司匹林等基础药物)和治疗组(22例,除基础用药外加用叶酸5mg口服每日3次),治疗前及治疗4周后测定患者空腹血清Hcy水平.结果:女性冠心病组患者血清Hcy水平(16.97±3.21μmol/L) 明显高于正常对照组(11.21±2.92μmol/L,P＜0.01).治疗组患者治疗4周后Hcy水平为10.34±5.63μmol/L,平均降低了36.4%,治疗前、后Hcy水平有极显著性差异(P＜0.01).结论:女性冠心病患者Hcy水平较高,补充叶酸可明显降低女性冠心病高Hcy血症患者的血浆Hcy水平,改善血管内皮功能.%Objective: To explore the effects of administration of additional dose of folic acid on serum homocysteic acid level of female coronary atherosclerotic patients in Yan'an, northwest Shanxi.Methods: 49 female patients with coronary heart disease and 50 normal controls were selected into the study.Of which 42 patients with high serum Hcy level (Hcy ＞15μmol/L ) were randomly divided into two therapeutic groups of which treated, respectively with conventional drugs such as aspirin, clopidogrel, stantins and conventional drugs plus additional use of folic acid. Results: The serum Hcy level of the female coronary patients is extremely high compared with that in normal controls ( P＜0. 01 ). Treated for 4 weeks the serum Hcy level of the therapeutic groups dicresed by 36. 4％ . The difference between the therapeutic group with the normal controls was very distinguished. (P＜0. 01) Conclusion: The serum Hcy level of the female coronary patients are quite higher, but given additional use of folic acid for 4 weeks later the serum Hcy levels of the patients decreased very significantly so as to function as the protection of the endotheliua of blood vessels of the body.