非小细胞肺癌合并慢性阻塞性肺疾病老年患者临床特点研究

摘要

Objective:To study the clinical characteristics of elderly patients with non-small cell lung cancer complicated with chronic obstructive pulmonary disease and to raise awareness of it.Method:A total of 87 patients with non-small cell lung cancer were enrolled in the study group.Select the same period in our hospital for treatment of chronic obstructive pulmonary disease in 103 patients with conventional group.Design the patient's basic situation questionnaire,arrange the patient smoking index,clinical disease and other information,and test the patient's lung function.Results:61patients(70.11%)with smoking index ≥400,26 patients(29.89%)with smoking index <400,59 patients(57.28%)with conventional smoking index ≥400,and 44 patients with smoking index 44(42. 72%),the difference between the two groups was statistically significant(P<0.05).The data of the patients in the observation group were hemoptysis,chest pain,weight loss,atelectasis,pleural effusion,hoarseness and fatiguew-ere32 cases(59.77%),48 cases(55.17%),23 cases(26.44%),36 cases(41.38%),37 cases(42.53%),6 cases (6.90%),21 cases(24.14%).Patients with conventional hemoptysis,chest pain,weight loss,atelectasis,pleural effusion,hoarseness,fatigue and other symptoms were 8 cases(8.73%),19 cases(18.45%),6 cases(5.83%), 12 cases(11.65%),3 cases(2.91%),1 case(0.97%),8 cases(8.73%),The difference between the two groups was statistically significant(P<0.05).The data of TLC,DLCO,FEV1 /FVC,RV /TLC in lung function index of regular group were(84.21 ± 10.92)L,(71.25 ± 9.85)ml/(min· mmHg),(51.26 ± 11.01)%,(53.66 ± 9. 88)%.The levels of TLC,DLCO,FEV1 /FVC and RV /TLC in the lung function index of observation group were (72.39 ± 8.72)L,(63.46 ± 10.98)ml/(min·mmHg),(46.85 ± 9.75)%,(44.35 ± 10.25)%.The difference be-tween the two groups was statistically significant(P<0.05).Conclusion:COPD complicated with NSCLC patients are common in male smokers,patients will be more severe hemoptysis,pleural effusion and other symptoms,lung function will decline.These indicators can provide a basis for the diagnosis of non-small cell lung cancer complicated with chronic obstructive pulmonary disease.%目的:研究老年非小细胞肺癌患者合并慢性阻塞性肺疾病(CO PD)的临床特点,提高对其的认识.方法:选取87例非小细胞肺癌并发慢性阻塞性肺疾病患者为观察组,选取同时期在我院接受治疗的慢性阻塞性肺疾病患者103例为常规组,设计患者基本情况调查表,整理得出患者吸烟指数、临床特点等资料,并检测患者肺功能.结果:观察组吸烟指数≥400的患者61例(70. 11%),吸烟指数<400的患者26例(29.89%),常规组吸烟指数≥400的患者59例(57.28%),吸烟指数<400的患者44例(42.72%),两组数据差异具有统计学意义(P<0.05).观察组患者咯血、胸痛、消瘦、肺不张、胸腔积液、声音嘶哑、乏力等症状数据分别为52例(59.77%)、48例(55. 17%)、23例(26.44%)、36例(41.38%)、37例(42.53%)、6例(6.90%)、21例(24.14%),常规组患者咯血、胸痛、消瘦、肺不张、胸腔积液、声音嘶哑、乏力等症状数据分别为8例(8.73%)、19例(18.45%)、6例(5.83%)、12例(11.65%)、3例(2.91%)、1例(0.97%)、8例(8.73%),组间数据差距具有统计学意义(P<0.05).常规组患者肺功能指数中的T LC、DLCO、FEV1/FVC、RV/T LC数据分别为(84.21 ± 10.92)L、(71.25 ± 9.85)ml/(min·mmHg)、(51.26 ± 11.01)%、(53.66 ± 9. 88)%,观察组患者肺功能指数中的 T LC、DLCO、FEV1/FVC、RV/T LC 数据分别为(72.39 ± 8. 72)L、(63.46 ± 10.98)ml/(min·m m Hg)、(46.85 ± 9.75)%、(44.35 ± 10.25)%,组间数据差异具有统计学意义(P<0.05).结论:非小细胞肺癌合并慢性阻塞性肺疾病患者常见于男性吸烟者,患者会出现较为严重的咯血,胸腔积液等症状,肺功能也会有所下降,这些指标均可为非小细胞肺癌合并慢性阻塞性肺疾病的诊断提供依据.