Objective:To study the therapeutical effect of rivaroxaban combined with antithrombotic pressure pump in prevention of deep vein thrombosis after artificial total hip arthroplasty (T HA ) and total knee arthroplasty (TKA) .Methods:68 patients with THA and TKA in our hospital were randomly divided into control group and ob-servation group ,34 cases in each group .The patients in the control group were taken rivaroxaban orally ,and pa-tients in the other group were treated with antithrombotic pressure pump on the basis of rivaroxaban .The levels of homocysteine ,c-reactive protein and D-dimer in the patients'blood were compared between the two groups .Besides , the incidence of postoperative deep vein thrombosis were compared in these two groups 1 week ,2 weeks ,3weeks af-ter surgery respectively .,and the postoperative complications were evaluated .Results :The levels of homocysteine , c-reactive protein and D-dimer in the observation group were significantly decreased than the control group (P<0 . 05) .Besides ,the incidence of postoperative deep vein thrombosis of the observation group (11 .76% ) was signifi-cantly lower than those in the control group(41 .18% ) and the postoperative complications (2 .94% ) was less when compared with the control group(23 .53% )(P<0 .05) .There's no bleeding in the observation group .Conclusion :Ri-varoxaban combined with antithrombotic pressure pump can reduce the incidence of postoperative deep vein thrombo-sis after THA and TKA successfully with less postoperative complications and low bleeding risk .%目的:探讨利伐沙班联合抗血栓压力泵预防人工髋膝关节置换术后深静脉血栓的疗效.方法:选取人工髋膝关节置换患者68例,随机分为观察组和对照组,每组34例,对照组口服给予利伐沙班,观察组在给予利伐沙班基础上辅以抗血栓压力泵治疗,比较两组治疗前后血液中同型半胱氨酸、C反应蛋白、D-二聚体水平,术后1、2、3周比较两组的深静脉血栓发生率,统计并发症发生情况.结果:与对照组相比,观察组血清中的同型半胱氨酸、C反应蛋白、D-二聚体水平显著降低(P<0.05),并且深静脉血栓的发生率为11.76%,显著低于对照组的41.18%(P<0.05),不良反应发生率为2.94%,也显著小于对照组的23.53%(P<0.05),未见出血情况发生.结论:利伐沙班联合抗血栓压力泵治疗可有效减少髋膝关节置换术后深静脉血栓的发生率,且并发症少.
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