醒脑汤治疗脑小血管病合并高同型半胱氨酸血症疗效研究

摘要

Objective:To observe the curative effect of Xingnao decoction in the treatment of cerebral small vessel disease combined with hyperhomocysteinemia and effects on the activities of life ability of patients with homo-cysteine and plasma index and mental state and cognitive ability.Methods:100 cases of cerebral small vessel disease (SVD)and homocysteine(Hcy)patients were enrolled in this study,divided into control group and observation group,control group with conventional western medicine treatment,the observation group was treated with Xingnao decoction in the treatment of treatment in the control group at the same time,treatment after 12 weeks to evaluate the clinical efficacy of the two groups and observe the changes of related indexes.Results:The total effective rate of control group was 70%,the total efficiency of the observation group was 88%,the clinical curative effect of observa-tion group was better than that of control group,the observation group(P<0.05);Hcy,folic acid and vitamin B12 were better than the control group,after treatment(P<0.05);the observation group ADL,MMSE,MoCA and ADAS-Cog were better than the control group after treatment(P<0.05).Conclusion:The Xingnao decoction is ef-fective in the treatment of cerebral small vessel disease complicated with hyperhomocysteinemia.It can improve the indexes of Hcy and improve the related functional status of patients.%目的:观察醒脑汤治疗脑小血管病合并高同型半胱氨酸血症的临床疗效以及对患者生活活动能力、同型半胱氨酸等血浆指标以及智能状态、认知能力的影响.方法:选取100例脑小血管病(SVD)合并同型半胱氨酸(Hcy)患者纳入本次研究,分为对照组、观察组,对照组以常规单纯西药治疗,观察组在对照组治疗的同时给予自拟醒脑汤治疗,治疗12周后评估两组的临床疗效并观察相关指标变化情况.结果:对照组总有效率为70.00%,观察组总有效率为88.00%,观察组临床疗效整体优于对照组(P<0.05);治疗后观察组 Hcy、叶酸与维生素B12均优于对照组(P<0. 05);治疗后观察组ADL、MMSE、MoCA、ADAS-Cog均优于对照组(P<0.05).结论:自拟醒脑汤治疗脑小血管病合并高同型半胱氨酸血症,疗效理想,可改善Hcy等指标提高患者相关功能状态.