method for promoting beneficial physiological revascularization of ischemic retinal tissue and screening method for identifying and evaluating the therapeutic efficacy of potential therapeutic agents for treating retinal neovascular diseases

摘要

METHOD FOR PROMOTING PHYSIOLOGICAL REVASCULARIZATION BENEFITS OF ISCHEMICAL RETINAL FABRIC AND TREATMENT METHOD FOR IDENTIFYING AND EVALUATING THERAPEUTIC EFFICACY FOR POTENTIAL NURAL DISEASE TREATURES The present invention provides a treatment method for promoting beneficial physiological revascularization of ischemic retinal tissue. The method comprises administering to a mammal suffering from retinal vascular ischemia a therapeutically effective amount of an angiostatic tryptophanyl tRNA synthetase (TrpRS) fragment, thereby inhibiting pathological neovascularization while promoting beneficial physiological revascularization of damaged retinal areas. In a preferred embodiment, the angiostatic TrpRS fragment is T2-TrpRS or T2-TrpRS-GD. Preferably, the mammal is a human patient suffering from retinal ischemia. A screening method for identifying and evaluating therapeutic agents for treating retinal neovascular diseases is also disclosed.