In order to compare the antimicrobial drug resistance of E .coli isolates to from different animals in Xinjiang ,454 isolates from pigs ,638 isolates from sheep and 89 isolates from cattle were conformed . Minimal inhibitory concentrations (MIC) of the antimicrobial drugs (including β‐lactams ,fluoroquinolo‐nes ,aminoglycosides and phenicol) to these isolates from pigs ,sheep and cattle were determined by the broth micro‐dilution method .The resistance rates of E .coli from pigs to ampicillin and amoxicillin/clavu‐lanic acid were 67 .0% and 63 .7% ,respectively ,resistance rates to other drugs between 10 .4%‐41 .2% ;the resistance rates of E .coli from sheep to apramycin and amoxicillin/clavulanic acid were 33 .9% and 21 . 2% ,respectively ,resistance rates to other drugs between 3 .1%‐15 .6% ;the resistance rates of E .coli from cattle to ampicillin and amoxicillin/clavulanic acid were 24 .4% and 8 .9% ,respectively ,resistance rates to other drugs between 1 .1%‐6 .7% .Multidrug resistance results ,showed that resistance to 2‐5 an‐timicrobials was dominated among E .coli isolates from pigs ;resistance to 0‐2 antimicrobials was domina‐ted among E .coli isolates from sheep ;resistance to 0‐1 antimicrobial was dominated among E .coli iso‐lates from cattle .Serious degree of resistance of E .coli to antimicrobial drugs descending order was iso‐lates from pig ,sheep and cattle ;multidrug resistance of E .coli from pigs was the most serious in Xin‐jiang .%为了比较新疆不同动物源大肠埃希菌对临床常用抗菌药物的耐药情况。从猪场、羊场和牛场分别分离猪源大肠埃希菌454株、羊源大肠埃希菌638株和牛源大肠埃希菌89株。用微量肉汤法对上述菌进行临床常用β‐内酰胺类、氟喹诺酮类、氨基糖苷类和酰胺醇类抗菌药物最小抑菌浓度测定。猪源大肠埃希菌对氨苄西林（67．0％）和阿莫西林／克拉维酸（63．7％）耐药率较高，其他药物耐药率在10．4％～41．2％之间；羊源大肠埃希菌对安普霉素（33．9％）和阿莫西林／克拉维酸（21．2％）耐药率较高，其他药物耐药率在3．1％～15．6％之间；牛源大肠埃希菌对氨苄西林（24．4％）和阿莫西林／克拉维酸（8．9％）耐药率较高，其他药物耐药率在1．1％～6．7％之间。多药耐药结果：猪源大肠埃希菌以2耐～5耐为主，羊源大肠埃希菌以0耐～2耐为主，牛源大肠埃希菌以0耐～1耐为主。新疆猪源大肠埃希菌对临床常用抗菌药物耐药情况最严重，羊源菌次之，牛源菌最轻；猪源大肠埃希菌多药耐药现象严重。
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