成年女性系统性红斑狼疮血清中抗黄体抗体与月经异常的相关性研究

摘要

目的:探讨成年女性系统性红斑狼疮(SLE)血清中抗黄体抗体与月经异常的相关性.方法:收集SLE患者及正常对照者的临床资料,详细记录入选研究对象的月经度生育情况,同时记录抗核抗体(ANA)等自身抗体的测定结果.采用酶联免疫吸附试验(ELISA)法检测患者血清中抗黄体抗体.结果:在入选的69例成年女性SLE患者中,26(38％)例患者抗黄体抗体阳性.而在40例健康对照者中,仅2(5％)例出现抗黄体抗体阳性.在入选的69例SLE患者中,29(42％)例患者的月经正常,40(58％)例患者出现月经异常.在40例健康对照者中,31(78％)例患者的月经正常,仅9(21％)例患者出现月经异常.有月经异常的SLE患者中抗黄体抗体的阳性率显著高于无月经异常的SLE患者(66％ vs 18％,P＜0.01),而在健康对照者中则未见有显著性差异.结论:SLE患者中抗黄体抗体的阳性率为38％,并可能与SLE的月经异常相关.%Objective: To verify the presence of anti-corpus luteum antibodies (anti-CoL) in systemic lupus erythematosus (SLE), as well as establish its possible correlation with menstrual disturbances in patients with SLE. Methods: Clinical data of 69 consecutive patients who fulfilled 4 or more of the ACR 1997 revised criteria for SLE were studied and were compared with 40 age-matched healthy controls, including anti-CoL. Results: 26 (38%) patients with SLE, and 2 (5%) of the healthy controls tested positive for anti-CoL. The presence of anti- CoL was significantly correlated to menstrual disturbance (P<0.01) in SLE patients. Conclusions: The presence of anti-CoL was 38% in SLE, and may correlate to menstrual disturbance.