高脂饮食诱导情绪障碍及药物干预研究进展

摘要

Recently,the incidence of metabolic disorder and depression gradually increases and clinical research demonstrated that metabolic disorder and depression often related to comorbidity.Western diet enriched in fat and refined sugar commonly results in some metabolic diseases in modem life,such as obesity,type 2 diabetic (T2DM) and metabolism syndrome.Moreover,it was found to be the risk factor for emotional disorder.But the exact mechanism underlying emotional disorder induced by high fat diet is still not fully elucidated,the probable mechanism including insulin and leptin resistant,inflammation,oxidative stress,neuronal apoptosis and brain rewarding circuitry.This paper reviews the potential mechanism of emotional disorder induced by high fat diet and the research progress on drug intervention.%近年来代谢性疾病和抑郁症的发病率逐渐上升,临床研究表明代谢紊乱疾病与抑郁症之间存在共病现象.富含高糖高脂的西方饮食通常可造成肥胖、糖尿病、代谢综合征等代谢紊乱性疾病,近期研究发现高脂饮食是情绪障碍发病的危险因素,然而具体高脂饮食对情绪紊乱的影响机制尚未明确,其可能机制包括胰岛素抵抗、瘦素抵抗、炎症、氧化应激、神经凋亡、大脑奖赏回路系统等.本文对近年来报道的高脂饮食诱发情绪障碍可能机制及药物研究进行阐述.