连续性血液净化对重症胰腺炎患者炎症因子、内毒素及肠道黏膜屏障功能的影响

摘要

Objective:To study the effects of continuous blood purification on inflammatory factors,endotoxin and intestinal mucosal barrier function in patients with severe acute pancreatitis.Methods:From February 2014 to January 2015,86 patients with severe pancreatitis were divided into the observation group (43 cases) and the control group (43 cases) according to coin method.The control group was treated with conventional therapy,and the observation group was treated with continuous blood purification on the basis of control group.Then the changes of inflammatory factors,endotoxin and intestinal mucosal barrier function were compared between the two groups before and after treatment,and the relief time of clinical symptom of two groups was analyzed.Results:The serum levels ofIL-6,IL-8,IL-1β,and TNF-α in the observation group were significantly higher than those in the control group (P ＜0.05).The levels of endotoxin,D-lactate and diamine oxidase in the observation group were significantly lower than those in the control group(P＜0.05).The relieving time of tenderness,abdominal pain and bloating in the observation group was significantly shorter than that in the control group (P ＜0.05).Conclusion:Continuous blood purification could effectively improve the levels of inflammatory factors,endotoxin and intestinal mucosal barrier function in patients with severe acute pancreatitis,and promote the rapid recovery of clinical symptoms in patients with severe acute pancreatitis.%目的:研究连续性血液净化对重症胰腺炎患者炎症因子、内毒素及肠道黏膜屏障功能的影响.方法:选取2014年2月至2015年1月本院收治的86例重症胰腺炎患者,按照投硬币法分为观察组(43例)和对照组(43例).对照组采取常规治疗,观察组在此基础上加以连续性血液净化治疗.比较两组患者治疗前后炎症因子、内毒素、肠道黏膜屏障功能变化情况,分析两组患者临床症状缓解时间.结果:治疗后,观察组血清白介素-6(IL-6)、白介素-8(IL-8)、白介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)、内毒素、D-乳酸、二胺氧化酶水平明显低于对照组(P＜0.05),压痛、腹痛、腹胀症状缓解时间显著短于对照组(P＜0.05).结论:连续性血液净化能有效改善重症胰腺炎患者炎症因子水平、内毒素及肠道黏膜屏障功能,促进患者临床症状快速恢复.