右美托咪啶预处理对肺癌根治术患者肺功能的影响

摘要

Objective:To observe the effect of dexmedetomidine on pulmonary function in patients undergoing radical sur-gery for lung cancer. Methods:Sixty patients undergoing radical resection of lung cancer were randomly divided into experimen-tal group and control group,the experimental group method using dexmedetomidine pretreatment,the control group using saline placebo pretreatment. The interleukin - 1β(IL - 1 β),interleukin - 10(IL - 10)of two group was detected in 30 min after one lung ventilation(T1),90 min after one lung ventilation(T2),1 postoperative days(T3)three point,and arterial blood gas analysis . Results :Compared with the control group ,T 2 ,T 3 IL - 1 β in the experimental group decreased significantly( P <0. 05),IL - 10 increased significantly(P < 0. 05). The alveolar oxygen partial pressure(PaO2 )of experimental group was sig-nificantly higher than that in control group after surgery,while alveolar partial pressure of carbon dioxide(PaCO2 )was signifi-cantly lower than the control group(P < 0. 05). Conclusion:Dexmedetomidine pretreatment can inhibit the expression of proin-flammatory cytokines,promote anti - inflammatory cytokine release,and can improve the postoperative lung function exchange, has certain protective effect on lung function in patients.%目的：观察右美托咪啶对肺癌根治术患者肺功能的影响。方法：选取60例择期行肺癌根治术患者，随机分为实验组和对照组，实验组采用右美托咪啶的方法进行预处理，对照组采用安慰剂生理盐水进行预处理。两组患者分别于单肺通气后30 min（T1）、单肺通气后90 min（T2）、术后1 d（T3）三个时点采集静脉血检测白细胞介素-1β（IL -1β）、白细胞介素-10（IL -10）浓度，同时采集动脉血行血气分析。结果：与对照组比较，实验组 T2，T3时点 IL -1β显著降低（P ＜0.05），IL -10显著升高（P ＜0.05）。实验组患者术后动脉血氧分压（PaO2）显著高于对照组，而二氧化碳分压（PaCO2）显著低于对照组（P ＜0.05）。结论：右美托咪啶预处理可抑制促炎性细胞因子的表达，促进抗炎性细胞因子的释放，且能改善患者术后肺交换功能，对患者肺功能有一定保护作用。