非诺贝特-羟丙基-β-环糊精固体分散体的制备及体外表征

摘要

Objective To prepare a water-insoluble drug fenofibrate (FNB) solid dispersion and investigate its related characteristics. Methods The FNB solid dispersion was prepared by using HP-β-CD as carrier material. The drug encapsulation efficiency,physical phase identification and in vitro dissolution test of the FNB solid dispersion were also accomplished. Results The FNB solid dispersion formed with HP-β-CD existed in an amorphous form. The in vitro dissolution of FNB from the solid dispersion was more rapid than that from the intact drug. Conclusion HP-β-CD may use as a good carrier in the preparation of FNB solid dispersion.%目的：制备水难溶性药物非诺贝特( Fenofibrate,FNB)的固体分散体并进行体外表征。方法以羟丙-β-环糊精( HP-β-CD)为载体材料,制备FNB的固体分散体,测定药物的包合率并进行物相鉴定及其体外溶出度考察。结果 FNB与HP-β-CD确已形成了固体分散体,且药物主要以无定型形式存在。固体分散体中FNB的体外溶出速率较原药显著提高。结论 HP-β-CD可用作FNB固体分散体制备的良好载体材料。