盆腔肿瘤IMRT下骨髓剂量-体积参数与急性血液学毒性相关性研究进展

摘要

There is a high risk of myelosuppression in pelvic malignant tumors during concurrent chemoradiotherapy. The dose-volume relationship of pelvic exposed bone marrow( bone) is related to acute hematological toxicity during radiotherapy and chemotherapy,but lacks recognized parameters in this respect. The hematopoietic capacity of the bone marrow(bone)in different parts of the pelvic cavity is heterogeneous,and the pelvic bone marrow near the central axis has the strongest hematopoietic capacity,namely functional bone marrow. The relationship between dose-volume parameters of pelvic functional bone marrow and acute hematologic toxicity during chemoradiotherapy of pelvic malignant tumors may be the future direction.%盆腔恶性肿瘤同期放化疗期间发生骨髓抑制的风险较高,盆腔受照射骨髓(骼)的剂量-体积关系与放化疗期间的急性血液学毒性存在相关,但缺乏此方面公认的参数.盆腔不同部位骨髓(骼)造血能力具有异质性,靠近体中轴的盆腔骨髓造血能力最强,即功能性骨髓.找准盆腔功能性骨髓的剂量-体积参数与盆腔恶性肿瘤放化疗期间急性血液学毒性的关系也许是今后发展方向.