表观遗传学对乳腺癌雌激素受体-α的调控

摘要

Recently,in the management of estrogen receptor(ER)positive breast canner,endocrine thera-py is the main treatment method;and estrogen receptor -α( ER-α) has obtained popularity as one of the most common targets .There are many known risk factors for ER function in breast canner such as ER gene mutation ;unbalanced microenvironment;signal transduction pathway disorders .While more and more attention is paid to the changes in ER expression and function induced by epigenetic aberrations .ER gene promoter methylation induces down regulation and deletion in ER expression ,which has not only a most highly incidence in epigenetic aberra-tions,but also a widen degree of research .Histone modification could influence ER -αexpression and function , either.However,the special mirco RNAs(miRNAs)are also implicated in the regulation of ER -α,and affect the therapy of tamoxifen in breast tumor .%目前，内分泌治疗是激素受体阳性乳腺癌主要的治疗手段，而雌激素受体-α（ Estrogen re-ceptor-α，ER-α）是这种治疗的主要靶分子之一。乳腺癌中ER的功能受很多因素影响，如ER基因的改变、微环境的改变、信号转导通路的变化等等，而其中表观遗传学的变化引起ER表达量及功能的改变日益引起重视。在表观遗传学的改变中，ER启动基因的甲基化是发生几率最高的，也是研究最广泛的，它能导致ER表达的下调或缺失。组蛋白修饰也可影响ER-α的表达及功能。而特定micro RNAs（ miR-NAs）能调节乳腺癌细胞ER-α的表达并影响乳腺癌对他莫昔芬（ Tamoxifen，TAM）反应性。