神经生长因子与化疗所致周围神经病变的相关性研究

摘要

Chemotherapy -induced peripheral neuropathy ( CIPN ) is one of the most common adverse effects in chemotherapy .The mechanism of CIPN has always been attracting researchers′attention.Recently,the intimate relationship between nerve growth factor and CIPN is one of the most hot topics .NGF protects neurons from damage of chemotherapy drugs through inhibiting apoptotsis and other pathway to relieve the neurotoxicity . However ,there are still many problems in the clinical application of exogenous NGF .To improve the mechanism of NGF in the development and application approach of CIPN ,treatment of chemotherapy -induced peripheral neu-rotoxicity is of great significance .%化疗所致周围神经病变（ Chemotherapy -induced peripheral neuropathy ，CIPN）是抗肿瘤治疗常见的副反应之一，其机制及防治一直是研究的热点。近年来，神经生长因子（Nerve growth factor，NGF）与CIPN的密切关系引起了众多学者的关注。 NGF可通过抑制细胞凋亡等途径保护神经元免受化疗药物的损害，从而减轻神经毒性。然而，外源性NGF的临床应用仍存在诸多问题，完善NGF在CIPN发病中的机制及应用途径的研究意义重大。