早期非小细胞肺癌立体定向放疗的相关研究

摘要

At present,approximately 20% of patients with clinically diagnosed early non-small cell lung cancer(NSCLC) are inoperable for their own reasons.Stereotactic radiotherapy(SRT)has the advantages of short treatment time,mild treatment-relat-ed injury and high local control rate. Currently,it has been used internationally as a first -line treatment for early incapacity of NSCLC.SRT has also achieved encouraging therapeutic effects in the treatment of early-stage NSCLC,but there are also some prob-lems to be solved urgently.This article aims to summarize the dosimetry,clinical indications and radiotherapy injury of SRT in the treatment of early-stage NSCLC.%目前临床上确诊的早期非小细胞肺癌患者中,约20%因自身原因不能手术.立体定向放射治疗具有治疗时间短、治疗相关性损伤轻及肿瘤局控率高的优势,当前国际上已经将其作为早期不能手术非小细胞肺癌的一线治疗方案.在早期能手术非小细胞肺癌的治疗中,立体定向放疗也达到了令人鼓舞的治疗效果,但也存在部分亟待解决的问题.本文将对立体定向放射治疗在早期非小细胞肺癌治疗中的剂量分割、临床适应症及放疗损伤进行综述.