单唾液酸四己糖神经节苷脂治疗新生儿缺氧缺血性脑病的疗效及对MMP-9水平的影响

摘要

Objective To observe the curative effect of monosiaotetrahxosyl ganglioside (MG1) in treating neonatal hypoxic ischemic encephalopathy ( HIE) , and the effect of the treatment on serum MMP-9 level. Methods Seventy-two cases of neonatus suffered from HIE were randomly divided into two groups (36 in each group) . One group was treated with brain protein hydrolysate (control group) and another was treated with brain protein hydrolysate combined GM1 ( observation group) . The NBNA assessment, serum MMP-9 level,CT results and total clinical curative effect were observed before and after the treatment. Results After the treatment, NBNA assessment and CT results were significantly improved while MMP-9 level was descended in both groups(P < 0. 05) . However, NBNA assessment was higher while MMP-9 levels were lower in observation group than that of controls(P < 0. 05) . The total curative effect of combined therapy was 94.44% that was significantly higher than control group (72. 22% ) (P < 0. 05) . Conclusion Combined MG1 and brain protein hydrolysate has satisfactory curative effect in the treatment of HIE. It can further reduce the release of MMP-9 to protect nerve damage.%目的 观察单唾液酸四己糖神经节苷脂(monosiaotetrahxosyl ganglioside,GM1)治疗新生儿缺氧缺血性脑病(hy-poxic ischemicencephalopathy,HIE)的疗效及对血清金属蛋白酶-9(MMP-9)水平的影响.方法 将72例HIE患儿分为观察组与对照组各36例,对照组给予脑蛋白水解物治疗,观察组在对照组用药基础上加用CM1治疗,观察两组患儿治疗前后新生儿神经行为测定( NBNA)评分、MMP-9水平、CT值及临床疗效.结果 两组患儿治疗后NBNA评分及CT值升高,MMP-9水平下降,差异均有统计学意义(P<0.05);治疗后观察组NBNA评分高于对照组,MMP-9水平低于对照组,差异有统计学意义(P<0.05);治疗总有效率观察组为94.44%,对照组为72.22%,差异有统计学意义(x2= 6.40,P