尼可地尔与单硝酸异山梨酯治疗不稳定性心绞痛的临床疗效分析

摘要

目的：观察尼可地尔与单硝酸异山梨酯治疗不稳定性心绞痛的临床效果。方法收集2012年7月至2013年7月在我院心内科进行诊治的90例不稳定性心绞痛患者，简单随机法分为治疗组和对照组各45例。两组均常规药物治疗，对照组加服单硝酸异山梨酯，治疗组加服尼可地尔。治疗60天后比较两组疗效。结果治疗组总有效率明显高于对照组，且治疗后心绞痛每天发作次数、疼痛持续时间、常规12导联心电图ST段压低的导联数（ NST）、ST段压低的总和（∑ST）临床疗效指标均明显低于对照组，差异有统计学意义（ P＜0.05）。结论常规药物治疗基础上加用尼可地尔治疗不稳定性心绞痛的有效率明显高于加用单硝酸异山梨酯，能有效改善患者的临床症状，且不良反应无差异，值得临床上进一步推广使用。%Objective To observe the clinical effect of nicorandil and isosorbide mononitrate( ISMN) in the treatment of unsta-ble angina pectoris.Methods Ninety patients with unstable angina treated in the department of cardiology of our hospital from July 2012 to July 2013 were randomly divided into treatment and control groups,45 in each group.In addition of the conventional drug treat-ment,the control group was treated with oral isosorbide mononitrate while the treatment group with nicorandil.Therapeutic effects were compared between the two groups after 60 days of the treatment.Results The total effective rate in the treatment group was significant-ly higher than that in the control group.The angina attack frequency,duration of pain every day,NST,and sigma ST clinical indicators in the treatment group were continually reduced when compared to the control group.The differences were all statistically significant( P<0.05).Conclusion Application of nicorandil based upon the conventional drug treatment can effectively improve clinical symptoms of unstable angina pectoris.It is worth popularizing in clinical use.