稳心颗粒联合小剂量胺碘酮对心脏瓣膜病并阵发性心房颤动患者心室重构的影响

摘要

Objective To investigate the impact of wenxin grannle combined with low - dose amiodarone on ventricular remodeling of valvular heart disease patients complicated with paroxysmal atrial fibrillation. Methods From April 2013 to December 2015,a total of 106 valvular heart disease patients complicated with paroxysmal atrial fibrillation were selected in the Department of Cardiology,the Traditional Chinese Medicine Hospital of Neijiang,and they were divided into control group and treatment group according to random number table,each of 53 cases. Patients of both groups received mechanical heart valve replacement and radiofrequency ablation;patients of control group were given low - dose amiodarone after surgery,while patients of treatment group were given wenxin grannle combined with low - dose amiodarone. Clinical effect,index of ventricular remodeling(including LVEF,LVEDD and LVSV)before treatment and after 3 months of treatment were compared between the two groups,and incidence of adverse reactions during the treatment was observed. Results The clinical effect of treatment group was statistically significantly better than that of control group(P < 0. 05). No statistically significant differences of LVEF, LVEDD or LVSV was found between the two groups before treatment( P > 0. 05);after 3 months of treatment,LVEF of treatment group was statistically significantly higher than that of control group,while LVEDD and LVSV of treatment group were statistically significantly lower than those of control group( P < 0. 05). After 3 months of treatment,LVEF of the two groups were statistically significantly higher than those before treatment,while LVEDD and LVSV of the two groups were statistically significantly lower than those before treatment(P < 0. 05). The incidence of adverse reactions of treatment group was statistically significantly lower than that of control group(P < 0. 05). Conclusion Wenxin grannle combined with low - dose amiodarone has certain clinical effect in treating valvular heart disease patients complicated with paroxysmal atrial fibrillation,can effectively reverse or delay the ventricular remodeling,and is relatively safe.%目的：探讨稳心颗粒联合小剂量胺碘酮对心脏瓣膜病并阵发性心房颤动患者心室重构的影响。方法选取2013年4月—2015年12月内江市中医医院心内科收治的心脏瓣膜病并阵发性心房颤动患者106例，按照随机数字表法分为对照组和治疗组，每组53例。两组患者入院后均行机械瓣膜置换术和射频消融术，对照组患者术后给予小剂量胺碘酮进行治疗，治疗组患者在对照组基础上联合稳心颗粒治疗。比较两组患者临床疗效、治疗前及治疗后3个月心室重构指标〔左心室射血分数（LVEF）、左心室舒张末期内径（LVEDD）、左心室搏出量（LVSV）〕，并观察两组患者治疗期间不良反应情况。结果治疗组患者临床疗效优于对照组（P <0.05）。治疗前，两组患者 LVEF、LVEDD和 LVSV 比较，差异无统计学意义（P >0.05）。治疗后3个月，治疗组患者 LVEF 高于对照组，LVEDD 和 LVSV 低于对照组（P <0.05）；且两组患者治疗后3个月 LVEF 高于治疗前，LVEDD 和 LVSV 低于治疗前（P <0.05）。治疗组患者治疗期间不良反应发生率低于对照组（P <0.05）。结论稳心颗粒联合小剂量胺碘酮治疗心脏瓣膜病并阵发性心房颤动的临床疗效确切，可有效逆转或延缓心室重构，且安全性较高。