步长稳心颗粒联合小剂量胺碘酮治疗阵发性房颤的临床疗效及安全性

摘要

目的：探讨步长稳心颗粒联合小剂量胺碘酮治疗阵发性房颤的临床疗效及安全性。方法：选取本院2012年收治的84例阵发性房颤患者作为研究对象，按照随机数字表法将其分为观察组和对照组各42例，观察组给予步长稳心颗粒联合小剂量胺碘酮治疗，对照组常规给予胺碘酮治疗，对两组患者的临床疗效进行评价，同时治疗期间对P波最大时限和P波离散度，以及治疗过程中的不良反应情况进行记录，并进行对比分析。结果：治疗6个月后，两组痊愈率比较差异无统计学意义（P>0.05），但观察组总有效率明显高于对照组，差异均有统计学意义（P<0.05）。两组患者Pmax和Pd均较治疗前明显降低，但观察组治疗后Pmax和Pd均明显优于对照组，差异均有统计学意义（P<0.01）。观察组治疗期间不良反应发生率明显低于对照组（P<0.05），且症状较为轻微。结论：步长稳心颗粒联合小剂量胺碘酮治疗阵发性房颤临床疗效满意，不良反应少且较轻微，具有良好的安全性，值得临床推广应用。%Objective:To investigate the clinical efficacy and safety of paroxysmal atrial fibrillation treating with Buchang Wenxin grain in combination with small dose amiodarone.Method:84 patients with paroxysmal atrial fibrillation in our hospital in 2012 were selected as the research subjects,they were randomly divided into the observation group and the control group,42 cases in each group.The observation group was given Buchang Wenxin grain in combination with small dose amiodarone,the control group was given conventional amiodarone treatment.The clinical effects of the two groups were evaluated,and during the treatment,the atrial fibrillation episodes per month,the duration of each attack,P wave maximum time limit and P wave dispersion degree,and the adverse reactions during the treatment were recorded and contrastively analyzed.Result:After six months treatment,the cure rate of the two groups had no statistical significance(P>0.05),but the total effective rate of the observation group was obviously higher than that of the control group,the difference was statistically significant(P<0.05).The Pmax and Pd of the two groups patients were significantly lower than treatment before,but the Pmax and Pd after treatment of the observation group were significantly better than the control group,the differences were statistically significant(P<0.01).The incidence of adverse reactions of the observation group during treatment was obviously lower than the control group(P<0.05),and the symptoms were mild.Conclusion:The clinical curative effect of paroxysmal atrial fibrillation treating with Buchang Wenxin grain in combination with small dose amiodarone is satisfied,it has few and mild adverse reactions,and has good security,is worthy of clinical popularization and application.