参麦注射液对冠心病患者血管内皮功能及炎性反应的影响研究

摘要

Objective To investigate the impact of shenmai injection on vascular endothelial function and inflammatory reaction of patients with coronary heart disease. Methods A total of 89 patients with coronary heart disease were selected in the Second People's Hospital of Nanyang from 2013 to 2014,and they were divided into control group( n = 42) and observation group(n = 47)according to random number table. Patients of both groups received conventional medical treatment,and patients of observation group continuously received extra shenmai injection for 3 weeks. Clinical effect,serum levels of hs-CRP,TNF-α, IL-6,NO and ET-1,and flow mediated endothelial diastolic function ( FMD) were compared between the two groups, hepatorenal function was closely monitored during treatment. Results The clinical effect of observation group was statistically significantly better than that of control group(Z = 2. 128,P < 0. 05). No statistically significant differences of serum level of hs-CRP,TNF-α,IL-6,NO or ET-1,or FMD was found between the two groups before treatment(P > 0. 05);after treatment, serum levels of hs-CRP,TNF-α,IL-6 and ET-1 of observation group were statistically significantly lower than those of control group,while serum NO level and FMD of observation group were statistically significantly higher than those of control group(P <0. 05). No one of the two groups occurred any serious adverse reactions or hepatorenal function damage during treatment. Conclusion Shenmai injection can significantly improve the clinical effect and vascular endothelial function of patients with coronary heart disease based on conventional medical treatment,can effectively relieve the inflammatory reaction.%目的 探讨参麦注射液对冠心病患者血管内皮功能及炎性反应的影响.方法 选择南阳市第二人民医院2013—2014年收治的冠心病患者89例,采用随机数字表法分为对照组42例和观察组47例.两组患者入院后均给予常规药物治疗,观察组患者在此基础上加用参麦注射液,连续治疗3周.比较两组患者临床疗效、治疗前后血清超敏C反应蛋白(hs-CRP)、肿瘤坏死因子 α(TNF-α)、白介素6(IL-6)、一氧化氮(NO)、内皮素-1(ET-1)水平及血流介导的内皮舒张功能(FMD),用药期间注意监测患者肝肾功能.结果 观察组患者临床疗效优于对照组(Z=2.128,P<0.05).两组患者治疗前血清hs-CRP、TNF-α、IL-6、NO、ET-1水平及FMD比较,差异均无统计学意义(P>0.05);观察组患者治疗后血清hs-CRP、TNF-α、IL-6、ET-1水平低于对照组,血清NO水平及FMD高于对照组(P<0.05).两组患者治疗期间均未出现严重不良反应及肝肾功能损伤.结论 在常规药物治疗基础上加用参麦注射液有助于提高冠心病治疗效果,可有效改善患者血管内皮功能并减轻炎性反应.