Objective To observe the clinical effect of interventional therapy of fiber bronchoscope on multi - drug resistant tuberculosis complicated with bronchial tuberculosis based on 3VHZALP/ 9VHZL chemotherapy regimens. Methods A total of 68 multi - drug resistant tuberculosis patients complicated with bronchial tuberculosis were selected in Hebei University Affiliated Hospital from August 2013 to August 2014,and they were divided into control group and test group according to therapeutic regimens,each of 32 cases. Patients of both groups received 3VHZALP/ 9VHZL chemotherapy regimens after admission,while patients of test group received extra interventional therapy of fiber bronchoscope;both groups continuously treated for 1 month. Sputum negative conversion rate after 1 month,3 months and 6 months of treatment,closure effect of cavities,absorption effect of invasive lesions and improvement of clinical symptoms were compared between the two groups,and incidence of adverse reactions during treatment was observed. Results The sputum negative conversion rate of test group was statistically significantly higher than that of control group after 1 month,3 months and 6 months of treatment,respectively(P <0. 05);closure effect of cavities and absorption effect of invasive lesions of test group were statistically significantly better than those of control group(P < 0. 05). The improvement rates of fever,cough,expectoration,chest pain and dyspnea of test group were statistically significantly higher than those of control group(P < 0. 05). The adverse reactions of the two groups were mild, and the adverse reactions disappeared after symptomatic treatment or transient drug withdrawal without affecting the treatment process. Conclusion Interventional therapy of fiber bronchoscope has certain clinical effect in treating multi - drug resistant tuberculosis complicated with bronchial tuberculosis based on 3VHZALP/ 9VHZL chemotherapy regimens,can effectively relieve the clinical symptoms,improve the sputum negative conversion rate,closure effect of cavities and absorption effect of invasive lesions,and is safe.%目的 观察3VHZALP/9VHZL化疗方案联合经纤维支气管镜介入治疗耐多药肺结核并支气管结核的临床疗效.方法 选取2013年8月—2014年8月河北大学附属医院收治的耐多药肺结核并支气管结核患者68例,按照治疗方案分为试验组36例和对照组32例.两组患者均给予3VHZALP/9VHZL化疗方案治疗,在此基础上试验组患者给予经纤维支气管镜介入治疗,均连续治疗1个月.记录两组患者治疗后1、3、6个月痰菌转阴率,治疗后空洞闭合效果、浸润病灶吸收效果及临床症状改善情况,同时观察治疗期间不良反应发生情况.结果 试验组患者治疗后1、3、6个月痰菌转阴率均高于对照组(P<0.05);治疗后试验组患者空洞闭合效果和浸润病灶吸收效果优于对照组(P<0.05).治疗后试验组患者发热、咳嗽、咳痰、胸痛及呼吸困难等临床症状改善率均高于对照组(P<0.05);两组患者不良反应均轻微,且经对症治疗或短暂停药后症状消失不影响继续治疗.结论 3VHZALP/9VHZL化疗方案联合经纤维支气管镜介入治疗耐多药肺结核并支气管结核的临床疗效确切,能有效改善患者临床症状,提高患者痰菌转阴率、空洞闭合及浸润病灶吸收效果,且安全性高.
展开▼
