鞘内注射右美托咪定联合吗啡对晚期恶性肿瘤患者镇痛的效果

摘要

Objective To study Discuss the effects of dexmedetomidine combined with morphine anaigesia on spinal in patients with advanced malignant tumor.Methods 42 patients with advanced malignant cancer pain were randomly divided into 2 groups,respectively received intrathecal injection of dexmedetomidine combined with morphine analgesia and intrathecal injection of morphine analgesia.To observe and the compare the analgesic effect,the incidence of adverse reactions and satisfaction and quality of life of patients.Results The analgesia effect,patient’ s satisfaction and quality of life of intrathecal injection of dexme-detomidine combined with morphine were superior to intrathecal injection of morphine alone ( P<0.05) .The incidence of consti-pation,vomiting,nausea,and itchy skin of intrathecal injection of dexmedetomidine combined with morphine were lower than those of pure morphine(P<0.05),but sleepiness rate was higher than that of simple morphine (P<0.05).Conclusion Intrathecal injection of dexmedetomidine combined with morphine can effectively reduce the dosage of morphine,enhance morphine analgesia effect,reduce the effect of morphine analgesia tolerance.It is a choice in clinical application.%目的：探讨右美托咪定鞘内注射联合吗啡对于晚期癌痛患者镇痛的临床效果。方法选取晚期恶性肿瘤患者42例，随机分为2组，分别采用鞘内注射右美托咪定联合吗啡镇痛和鞘内注射吗啡镇痛。观察镇痛效果、不良反应发生率和患者满意度及生活质量评分，并进行比较。结果鞘内注射右美托咪定联合吗啡镇痛效果、患者满意度及生活质量评分均优于鞘内单纯注射吗啡（P＜0．05），便秘、呕吐、恶心和皮肤瘙痒的发生率低于单纯吗啡（P＜0．05），但嗜睡发生率高于单纯吗啡（P＜0．05）。结论鞘内注射右美托咪定联合吗啡可以有效减少吗啡用量，增强吗啡镇痛效果，减轻吗啡镇痛耐受作用，是临床用药的一种选择。