c-kit蛋白表达与小细胞肺癌患者临床特征及预后的关系

摘要

Objective To investigate the relationship between c-kit protein expression and clinical characteristics and prognosis in patients with small cell lung cancer( SCLC) .Methods 159 cases of SCLC were divided into the observation group (77 cases) and the control group(82 cases) according to c-kit protein expression in SCLC tissue or not,and the clinical charac-teristics and prognosis between the 2 groups were compared.Results There were no obvious differences in the gender,age,body mass index,smoking history,tumor size,N grade and M grade between the 2 groups( P>0.05) ,while the T grade in the observa-tion group was obviously higher than that of the control group(P<0.05).1-year survival rate in the observation group was obvi-ously lower than that of the control group(P<0.05).Conclusion There is a certain relationship between T grade and c-kit pro-tein expression and prognosis in patients with SCLC.%目的：探讨小细胞肺癌（ SCLC）组织中c-kit蛋白表达与其临床特征及预后的关系。方法选取159例SCLC患者作为研究对象，根据SCLC组织是否表达c-kit蛋白将上述研究对象分为观察组（77例）与对照组（82例），现比较两组患者的临床特征及预后。结果两组患者性别、年龄、体质指数、吸烟史、肿瘤大小、N分级、M分级方面相比差异无统计学意义（P＞0．05），观察组T分级显著高于对照组，差异有统计学意义（P＜0．05）。观察组1年生存率显著低于对照组，差异有统计学意义（P＜0．05）。结论 c-kit蛋白表达与SCLC患者T分级及预后有一定的关系。