目的：分析及研究急性白血病化疗后继发感染性休克患者病原菌分布及耐药性情况。方法选取1363例急性白血病患者为研究对象，统计化疗后继发感染性休克的发生率，然后分析比较感染性休克者病原菌分布情况及其耐药性。结果 1363例急性白血病患者共75例发生感染性休克，发生率为5．50％，75例患者共检出104株病原菌，其中革兰阴性菌所占比例明显高于革兰阳性菌与真菌，革兰阴性菌对哌拉西林、氨苄西林及头孢唑林的耐药率明显高于对其他药物的耐药率，而革兰阳性菌对哌拉西林、氨苄西林及庆大霉素的耐药率明显高于对其他药物的耐药率，P均＜0．05，均有显著性差异。结论急性白血病患者化疗后继发感染性休克患者的病原菌以革兰阴性菌为主，且其耐药情况突出，应引起重视。%Objective To analyze and study the distribution and drug resistance of pathogenic bacteria in acute leukemia patients with secondary septic shock after the chemotherapy .Methods 1 363 patients with acute leukemia were selected as re-search object ,and the rate of secondary septic shock after the chemotherapy of acute leukemia was analyzed ,and the distribution and drug resistance of pathogenic bacteria were analyzed and compared .Results In 1 363 patients,75 cases had septic shock , the rate was 5.50%,and 104 pathogenic bacteria were detected from 75 patients,the proportion of Gram-negative bacteria was higher than Gram-positive bacteria and fungus ,and the drug resistance rates of Gram-negative bacteria to piperacillin ,ampicillin and cefazolin were higher than those of other drugs ,the drug resistance rates of Gram-positive bacteria to piperacillin ,ampicillin and gentamicin were all higher than those of other drugs ,all P<0.05,there had significant differences .Conclusion Gram-nega-tive bacteria is the main pathogenic bacteria in acute leukemia patients with secondary septic shock after the chemotherapy ,the drug resistance is obvious and need special attention .
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