急性白血病化疗后继发感染性休克患者血清炎性介质变化研究

摘要

目的 观察与分析急性白血病化疗后继发感染性休克患者血清炎性介质变化状态.方法 选取56例急性白血病患者化疗后继发感染性休克患者为A组,56例急性白血病患者化疗后未继发感染性休克患者为B组,56例同龄健康者为C组,然后检测与比较3组血清炎性介质水平,同时将A组中不同休克严重程度患者的血清指标进行比较,并比较A组与B组不同分类(淋巴细胞与非淋巴细胞白血病)患者的检测结果.结果 血清炎症介质水平,如肿瘤坏死因子(TNF-α)、白细胞介素(IL-4)、IL-6、IL-10及其他炎性介质,如前列腺素E2(PGE2)、可溶性细胞间粘附分子(sICAM-1)、血管细胞间粘附分子(sVCAM-1)及sCD44,A组>B组>C组,重度患者>中度患者>轻度患者(P均group B >group C, severe shock >moderate shock>mild shock ( all P<0.05 ) .The above serum inflammatory mediators and other inflammatory factors levels of different types in group A were higher than those in group B, and the above mediators in lymphocytic leukemia of group A and group B were higher than those in nonlymphocytic leukemia (all P<0.05).Conclusion The serum inflammatory mediators of patients with secondary septic shock after chemotherapy for acute leukemia show higher expression state,and the influence of shock degree and leukemia types for the expression are great.