目的：探讨全胸腔镜肺叶切除术与传统开胸手术治疗早期非小细胞肺癌的临床疗效。方法将早期非小细胞肺癌患者76例随机分为2组，其中观察组38例行全胸腔镜肺叶切除术，对照组38例行传统开胸肺叶切除术，对比2组患者的临床疗效及并发症。结果观察组的手术时间、术中出血量、引流管放置时间、住院时间和VAS疼痛评分均明显低于对照组（P＜0．05），2组淋巴结清扫个数的差异无统计学意义（P＞0．05）；2组术前血清TNF-α、CRP、IL-6、IL-10含量的差异无统计学差异（P＞0．05），术后2组TNF-α、CRP、IL-6及IL-10的水平均显著升高（P＜0．05），观察组术后3 d血清TNF-α、CRP、IL-6、IL-10水平明显低于对照组（ P＜0．05）。观察组的并发症总发生率为13．16％，明显低于对照组的44．74％，差异有统计学意义（P＜0．05）。结论全胸腔镜肺叶切除术治疗早期非小细胞肺癌的临床疗效优于传统开胸手术，值得临床推广应用。%Objective To study the efficacy of full thoracoscopic lobectomy and conventional thoracotomy in the treat -ment of early non-small cell lung cancer .Methods 76 non-small cell lung cancer patients were divided into 2 groups ,38 cases treated with completely video-assisted thoracoscopic lobectomy was the observation group and 38 cases received conventional tho-racotomy was the control group .Clinical efficacy and adverse reactions of the 2 groups were compared .Results The operation time,bleeding volume,the time of drainage,hospital stay and VAS pain score in the observation group were significantly lower than those of the control group (P<0.05),and there was no significant difference in the number of lymph node dissection be-tween the 2 groups(P>0.05);There was no significant difference in serum TNF-α、CRP、IL-6、IL-10 in the two groups before op-eration(P>0.05),but after operation they all rise significantly (P<0.05),the levels of these indicators in the observation group were significantly lower than those of the control group (P<0.05);the total complication rate in the observation group was 13. 16%,which was significantly lower than that of the control group (P<0.05).Conclusion The full thoracoscopic lobectomy has better clinical efficacy than conventional thoracotomy for early non-small cell lung cancer ,which is worthy of clinical promotion .
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