目的：采用长春新碱序贯环磷酰胺治疗恶性淋巴瘤，分析其治疗效果。方法选取60例恶性淋巴瘤患者，分为长春新碱联合环磷酰胺治疗组、长春新碱序贯环磷酰胺治疗组，观察比较其不良反应、治疗效果、生存率。结果序贯组发热、胃肠道反应、肝功能损伤、白细胞减少发生率均低于联合组，差异有统计学意义（ P＜0．05）；序贯组完全缓解、部分缓解、总有效率均优于联合组，差异有统计学意义（P＜0．05）；序贯组半年、1年、2年生存率均明显高于联合组，差异有统计学意义（P＜0．05）。结论采用VCR序贯CTX治疗恶性淋巴瘤，能够降低治疗引起的不良反应，增加治疗效果，提高生存率，值得临床推广应用。%Objective To study the clinical efficacy of vincristine sequential cyclophosphamide for malignant lymphoma . Methods 60 malignant lymphoma patients were divided into vincristine combined therapy with cyclophosphamide group and vin -cristine sequential cyclophosphamide treatment group ,the adverse reactions ,therapeutic effects and survival rates were compared . Results Fever,gastrointestinal reaction,liver function damage,leukopenia of sequential group were lower than the joint group , there was statistically significant difference (P<0.05);complete response,partial response,the total effective rate of sequential group were higher than the joint group ,there was statistically significant difference ( P<0.05);6-month,1-,2-year survival rates of sequential group were significantly higher than those of joint group ,there was statistically significant difference (P<0.05). Conclusion VCR sequential CTX for malignant lymphoma can reduce adverse reaction caused by treatment ,increase therapeutic effect,improve survival rate,and it is worthy of clinical popularization and application .
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