Objective To investigate relationship between expression of serum VHL ,HIF-1αand HIF-2αand the clini-copathological features in renal carcinoma .Methods 43 patients with renal cell carcinoma were the renal carcinoma group and 40 healthy examinees were the control group .Levels of serum VHL ,HIF-1αand HIF-2αin the 2 groups were detected .The maxi-mum diameters of carcinoma foci were detected .Studies are needed with follow up of 6 months to record relapse cases .Relation-ship between expression of serum VHL ,HIF-1αand HIF-2αand the clinicopathological feature in renal carcinoma were analyzed . Results Level of serum VHL in the renal carcinoma group was obviously lower than the control group ,while levels of HIF-1αand HIF-2αwere obviously higher(P<0.01).Expression of serum VHL,HIF-1αand HIF-2αwas not related to age and sex in renal carcinoma(P>0.05),while was significantly correlated with pathological grade ,clinical stages,size of carcinoma and lym-phatic metastasis(P<0.01).All patients of renal carcinoma were followed up by 6 months with 6 recurrent cases and 37 non-re-current cases .Level of serum VHL in recurrent cases was obviously lower , while levels of HIF-1αand HIF-2αwere obviously higher than non-recurrent cases,there had significant differences (P<0.05,P<0.01).Conclusion Levels of serum VHL,HIF-1αand HIF-2αare correlated significantly with pathological grade , clinical stages , size of carcinoma and lymphatic metastasis , which indicates indexes mentioned above could be important indicators of judging occurrence ,development and recurrence of renal carcinoma.%目的：探讨血清VHL，HIF-1α和HIF-2α的表达水平与肾癌临床病理特征的关系。方法收集肾癌患者43例（肾癌组）和同期健康查体者40例（对照组）；检测两组血清VHL，HIF-1α和HIF-2α水平；测定患者癌灶最大直径；对所有患者进行6个月随访。结果与对照组比较，肾癌患者血清VHL水平明显降低，而HIF-1α和HIF-2α水平明显升高（P＜0．01）；肾癌患者血清VHL、HIF-1α和HIF-2α表达与患者年龄、性别无明显相关（P＞0．05），而与病理分级、临床分期、癌灶大小以及淋巴结转移显著相关（P＜0．01）；所有肾癌患者随访6个月，6例复发，37例未复发，复发组患者术后血清VHL水平明显低于未复发组，而HIF-1α和HIF-2α水平明显高于未复发组，比较差异均有统计学意义（ P＜0．05， P＜0．01）。结论血清VHL，HIF-1α和HIF-2α水平与肾癌病理分级、临床分期、癌灶大小以及淋巴结转移显著相关，提示上述指标可成为判定肾癌发生、发展以及复发的重要指标。
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