放化疗联合生物靶向治疗对乳腺癌早期改良根治术后患者远期生存率的影响

摘要

目的 分析放化疗联合生物靶向治疗对乳腺癌早期改良根治术后患者远期生存率的影响.方法 选取乳腺癌早期改良根治术患者86例,将其随机分为对照组与联合组,对照组患者术后行放化疗(多西紫杉醇结合顺铂化疗+三维适形放疗)辅助治疗,联合组在对照组基础上行生物靶向(曲妥珠单抗)治疗,对比两组患者术后并发症发生率及生活质量,比较两组患者术后1年、3年局部复发率、远处转移率、生存率.结果 联合组患者并发症发生率(4.65％)明显低于对照组(44.19％),差异显著(P<0.05);联合组术后生活质量各指标评分均高于对照组,差异明显(P<0.05);两组患者治疗后1年复发率、远处转移率、生存率比较均无明显差异(P>0.05);联合组术后3年远处转移率、复发率均低于对照组,但差异不明显(P>0.05).结论 乳腺癌早期改良根治术后患者实施放化疗联合生物靶向治疗可有效减少并发症提高其生活质量,远期生存率较好,可在临床上推广应用.%Objective To analyze influence of radiotherapy and chemotherapy combined with biological targeted therapy on long-term survival rate of breast cancer patients after early modified radical mastectomy.Methods 86 cases of breast cancer patients after early modified radical mastectomy were randomly divided into the control group and the combined group.The control group were given radiotherapy and chemotherapy(docetaxel combined with cisplatin chemotherapy plus three-dimensional conformal radiotherapy)adjuvant therapy after operation,and the combined group were given biological targeted therapy(trastuzumab)on the basis of the control group.Incidence of postoperative complications and quality of life were compared in the 2 groups,and 1-,3-year local recurrence rates,distant metastasis rates and survival rates were compared in the 2 groups.Results The incidence rate of complications in the combined group(4.65％)was significantly lower than that of the control group(44.19％),there had significant difference(P<0.05).The scores of quality of life of the combined group after operation were significantly higher than those of the control group(P<0.05).There were no significant differences in 1-year recurrence rate,distant metastasis rate and survival rate between the 2 groups after treatment(P>0.05).3-year distant metastasis rate and recurrence rate after operation of the combination group were lower than those of the control group,there had no significant differences(P>0.05).Conclusion Radiotherapy and chemotherapy combined with biological targeted therapy for breast cancer patients after early modified radical mastectomy can effectively reduce complications and improve life quality of patients,with better long-term survival rate.It can be widely used in clinical.